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Cleavage Inhibition of the Murine Coronavirus Spike Protein by a Furin-Like Enzyme Affects Cell-Cell but Not Virus-Cell Fusion

Cleavage of the mouse hepatitis coronavirus strain A59 spike protein was blocked in a concentration-dependent manner by a peptide furin inhibitor, indicating that furin or a furin-like enzyme is responsible for this process. While cell-cell fusion was clearly affected by preventing spike protein cle...

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Bibliografiske detaljer
Main Authors: de Haan, Cornelis A. M., Stadler, Konrad, Godeke, Gert-Jan, Bosch, Berend Jan, Rottier, Peter J. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC415802/
https://ncbi.nlm.nih.gov/pubmed/15141003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.11.6048-6054.2004
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