Cleavage of Group 1 Coronavirus Spike Proteins: How Furin Cleavage Is Traded Off against Heparan Sulfate Binding upon Cell Culture Adaptation

A longstanding enigmatic feature of the group 1 coronaviruses is the uncleaved phenotype of their spike protein, an exceptional property among class I fusion proteins. Here, however, we show that some group 1 coronavirus spike proteins carry a furin enzyme recognition motif and can actually be cleav...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: de Haan, C. A. M., Haijema, B. J., Schellen, P., Schreur, P. Wichgers, te Lintelo, E., Vennema, H., Rottier, P. J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395124/
https://ncbi.nlm.nih.gov/pubmed/18400867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00074-08
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados