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Cleavage of Group 1 Coronavirus Spike Proteins: How Furin Cleavage Is Traded Off against Heparan Sulfate Binding upon Cell Culture Adaptation

A longstanding enigmatic feature of the group 1 coronaviruses is the uncleaved phenotype of their spike protein, an exceptional property among class I fusion proteins. Here, however, we show that some group 1 coronavirus spike proteins carry a furin enzyme recognition motif and can actually be cleav...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: de Haan, C. A. M., Haijema, B. J., Schellen, P., Schreur, P. Wichgers, te Lintelo, E., Vennema, H., Rottier, P. J. M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology (ASM) 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395124/
https://ncbi.nlm.nih.gov/pubmed/18400867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00074-08
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