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Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
The SARS-CoV-2 coronavirus responsible for the global pandemic contains a unique furin cleavage site in the spike protein (S) that increases viral infectivity and syncytia formation. Here, we show that O-glycosylation near the furin cleavage site is mediated by specific members of the GALNT enzyme f...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | bioRxiv |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Cold Spring Harbor Laboratory
2021
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7872346/ https://ncbi.nlm.nih.gov/pubmed/33564758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.02.05.429982 |
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