Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the host cell receptor ACE2 and undergoing virus-host membrane fusion. Fusion is triggered by the protease TMPRSS2, which processes the viral Spike (S) protein to reveal the fusion peptide. SARS-CoV-2 has evolve...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Papa, Guido, Mallery, Donna L., Albecka, Anna, Welch, Lawrence G., Cattin-Ortolá, Jérôme, Luptak, Jakub, Paul, David, McMahon, Harvey T., Goodfellow, Ian G., Carter, Andrew, Munro, Sean, James, Leo C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7861537/
https://ncbi.nlm.nih.gov/pubmed/33493182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009246
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