Coronavirus Escape from Heptad Repeat 2 (HR2)-Derived Peptide Entry Inhibition as a Result of Mutations in the HR1 Domain of the Spike Fusion Protein

Peptides based on heptad repeat (HR) domains of class I viral fusion proteins are considered promising antiviral drugs targeting virus cell entry. We have analyzed the evolution of the mouse hepatitis coronavirus during multiple passaging in the presence of an HR2-based fusion inhibitor. Drug-resist...

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Main Authors: Bosch, Berend Jan, Rossen, John W. A., Bartelink, Willem, Zuurveen, Stephanie J., de Haan, Cornelis A. M., Duquerroy, Stephane, Boucher, Charles A. B., Rottier, Peter J. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258948/
https://ncbi.nlm.nih.gov/pubmed/18077706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02287-07
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