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A Water-mediated and Substrate-assisted Catalytic Mechanism for Sulfolobus solfataricus DNA Polymerase IV
DNA polymerases are enzymes responsible for the synthesis of DNA from nucleotides. Understanding their molecular fundamentals is a prerequisite for elucidating their aberrant activities in diseases such as cancer. Here we have carried out ab initio quantum mechanical/molecular mechanical (QM/MM) stu...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519035/ https://ncbi.nlm.nih.gov/pubmed/17375926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja068821c |
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