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Polymerase-tailored variations in the Water-Mediated and Substrate-Assisted Mechanism for Nucleotidyl Transfer: Insights from a Study of T7 DNA Polymerase
The nucleotidyl transfer reaction catalyzed by DNA polymerases is the critical step governing the accurate transfer of genetic information during DNA replication and its malfunctioning can cause mutations leading to human diseases including cancer. Here utilizing ab initio quantum mechanical/molecul...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801548/ https://ncbi.nlm.nih.gov/pubmed/19389406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.04.029 |
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