Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

BACKGROUND: Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipid (GSL) hydrolases in lysosomes. Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin deficiencies. RESULTS: Our hypomorphic pro...

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Autors principals: Sun, Ying, Jia, Li, Williams, Michael T, Zamzow, Matt, Ran, Huimin, Quinn, Brian, Aronow, Bruce J, Vorhees, Charles V, Witte, David P, Grabowski, Gregory A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518924/
https://ncbi.nlm.nih.gov/pubmed/18673548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-76
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