Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

BACKGROUND: Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipid (GSL) hydrolases in lysosomes. Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin deficiencies. RESULTS: Our hypomorphic pro...

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Autores principales: Sun, Ying, Jia, Li, Williams, Michael T, Zamzow, Matt, Ran, Huimin, Quinn, Brian, Aronow, Bruce J, Vorhees, Charles V, Witte, David P, Grabowski, Gregory A
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518924/
https://ncbi.nlm.nih.gov/pubmed/18673548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-76
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