Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

BACKGROUND: Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipid (GSL) hydrolases in lysosomes. Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin deficiencies. RESULTS: Our hypomorphic pro...

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Bibliographic Details
Main Authors: Sun, Ying, Jia, Li, Williams, Michael T, Zamzow, Matt, Ran, Huimin, Quinn, Brian, Aronow, Bruce J, Vorhees, Charles V, Witte, David P, Grabowski, Gregory A
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518924/
https://ncbi.nlm.nih.gov/pubmed/18673548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-76
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