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Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells
Gossypol, a cottonseed extract derivative, acts as a BH3-mimetic, binding to the BH3 pocket of antiapoptotic proteins and displacing pro-death partners to induce apoptosis. However, knowledge on the molecular underpinnings of its downstream effects is limited. Since chronic lymphocytic leukemia (CLL...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518898/ https://ncbi.nlm.nih.gov/pubmed/18566329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-12-126946 |
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