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Circular DNA and DNA/RNA Hybrid Molecules as Scaffolds for Ricin Inhibitor Design

Ricin Toxin A-chain (RTA) catalyzes the hydrolytic depurination of A(4324), the first adenosine of the GAGA tetra-loop portion of 28S eukaryotic ribosomal RNA. Truncated stem-loop versions of the 28S rRNA are RTA substrates. Here, we investigate circular DNA and DNA/RNA hybrid GAGA sequence oligonuc...

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Main Authors: Sturm, Matthew B., Roday, Setu, Schramm, Vern L.
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518448/
https://ncbi.nlm.nih.gov/pubmed/17417841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja068054h
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