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Circular DNA and DNA/RNA Hybrid Molecules as Scaffolds for Ricin Inhibitor Design
Ricin Toxin A-chain (RTA) catalyzes the hydrolytic depurination of A(4324), the first adenosine of the GAGA tetra-loop portion of 28S eukaryotic ribosomal RNA. Truncated stem-loop versions of the 28S rRNA are RTA substrates. Here, we investigate circular DNA and DNA/RNA hybrid GAGA sequence oligonuc...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518448/ https://ncbi.nlm.nih.gov/pubmed/17417841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja068054h |
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