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Small molecule inhibitors targeting the interaction of ricin toxin A subunit with ribosomes

Ricin toxin A subunit (RTA) removes an adenine from the universally conserved sarcin/ricin loop (SRL) on eukaryotic ribosomes thereby inhibiting protein synthesis. No high affinity and selective small-molecule therapeutic antidotes have been reported against ricin toxicity. RTA binds to the ribosoma...

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Dettagli Bibliografici
Pubblicato in:ACS Infect Dis
Autori principali: Li, Xiao-Ping, Harijan, Rajesh K., Kahn, Jennifer N., Schramm, Vern L., Tumer, Nilgun E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7678679/
https://ncbi.nlm.nih.gov/pubmed/32428396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00127
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