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Small molecule inhibitors targeting the interaction of ricin toxin A subunit with ribosomes
Ricin toxin A subunit (RTA) removes an adenine from the universally conserved sarcin/ricin loop (SRL) on eukaryotic ribosomes thereby inhibiting protein synthesis. No high affinity and selective small-molecule therapeutic antidotes have been reported against ricin toxicity. RTA binds to the ribosoma...
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| Publicado en: | ACS Infect Dis |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7678679/ https://ncbi.nlm.nih.gov/pubmed/32428396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00127 |
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