Common Pharmacophore of Structurally Distinct Small-Molecule Inhibitors of Intracellular Retrograde Trafficking of Ribosome Inactivating Proteins

We reported previously (±)-2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one [(±)-Retro-2(cycl)] as the chemical structure of Retro-2 that showed mouse protection against ricin, a notorious ribosome inactivating protein (RIP). Herein we report our chemical resolution of (±)-Retro-2(...

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Библиографические подробности
Главные авторы: Yu, Shichao, Park, Jewn Giew, Kahn, Jennifer Nielsen, Tumer, Nilgun E., Pang, Yuan-Ping
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844963/
https://ncbi.nlm.nih.gov/pubmed/24292269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03397
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