Small-Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Doorstop Approach

Ribosome-inactivating proteins (RIPs) are toxic because they bind to 28S rRNA and depurinate a specific adenine residue from the α-sarcin/ricin loop (SRL), thereby inhibiting protein synthesis. Shiga-like toxins (Stx1 and Stx2), produced by Escherichia coli, are RIPs that cause outbreaks of foodborn...

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Main Authors: Pang, Yuan-Ping, Park, Jewn Giew, Wang, Shaohua, Vummenthala, Anuradha, Mishra, Rajesh K., McLaughlin, John E., Di, Rong, Kahn, Jennifer Nielsen, Tumer, Nilgun E., Janosi, Laszlo, Davis, Jon, Millard, Charles B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063779/
https://ncbi.nlm.nih.gov/pubmed/21455295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017883
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