Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design

Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism. Current treatment for post exposure of BoNTA uses antibodies that are effective in neutralizing the extracellular toxin to prevent further intoxication but generally cannot rescue already into...

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Main Authors: Pang, Yuan-Ping, Vummenthala, Anuradha, Mishra, Rajesh K., Park, Jewn Giew, Wang, Shaohua, Davis, Jon, Millard, Charles B., Schmidt, James J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2009
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771286/
https://ncbi.nlm.nih.gov/pubmed/19901994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007730
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