Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design

Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism. Current treatment for post exposure of BoNTA uses antibodies that are effective in neutralizing the extracellular toxin to prevent further intoxication but generally cannot rescue already into...

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Detalhes bibliográficos
Main Authors: Pang, Yuan-Ping, Vummenthala, Anuradha, Mishra, Rajesh K., Park, Jewn Giew, Wang, Shaohua, Davis, Jon, Millard, Charles B., Schmidt, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771286/
https://ncbi.nlm.nih.gov/pubmed/19901994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007730
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