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Ring-Closing Metathesis for the Synthesis of a Highly G-Quadruplex Selective Macrocyclic Hexaoxazole Having Enhanced Cytotoxic Potency
The synthesis of a 24-membered macrocyclic hexaoxazole via ring-closing metathesis is described. The target compound selectively stabilizes G-quadruplex DNA with no detectable stabilization of duplex DNA. An MTT cytotoxicity assay indicated that this unsaturated macrocyclic hexaoxazole exhibits sign...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518403/ https://ncbi.nlm.nih.gov/pubmed/18515097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.05.032 |
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