Ring-Closing Metathesis for the Synthesis of a Highly G-Quadruplex Selective Macrocyclic Hexaoxazole Having Enhanced Cytotoxic Potency

The synthesis of a 24-membered macrocyclic hexaoxazole via ring-closing metathesis is described. The target compound selectively stabilizes G-quadruplex DNA with no detectable stabilization of duplex DNA. An MTT cytotoxicity assay indicated that this unsaturated macrocyclic hexaoxazole exhibits sign...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Satyanarayana, Mavurapu, Rzuczek, Suzanne G., LaVoie, Edmond J., Pilch, Daniel S., Liu, Angela, Liu, Leory F., Rice, Joseph E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518403/
https://ncbi.nlm.nih.gov/pubmed/18515097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.05.032
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky