Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

Adults with Down syndrome (DS) develop Alzheimer neurofibrillary degeneration in the brain, but the underlying molecular mechanism is unknown. Here, we report that the presence of an extra copy of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A (Dyrk1A) gene due to trisomy 21 re...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Liu, Fei, Liang, Zhihou, Wegiel, Jerzy, Hwang, Yu-Wen, Iqbal, Khalid, Grundke-Iqbal, Inge, Ramakrishna, Narayan, Gong, Cheng-Xin
Формат: Artigo
Язык:Inglês
Опубликовано: The Federation of American Societies for Experimental Biology 2008
Предметы:
Research Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518253/
https://ncbi.nlm.nih.gov/pubmed/18509201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-104539
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы