The Link Between DYRK1A Overexpression and Several-fold Enhancement of Neurofibrillary Degeneration with 3-Repeat Tau Protein in Down Syndrome

Triplication of chromosome 21 in Down syndrome (DS) results in overexpression of the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A gene (DYRK1A). DYRK1A phosphorylates cytoplasmic tau protein and appears in intraneuronal neurofibrillary tangles (NFTs). We have pre...

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Main Authors: Wegiel, Jerzy, Kaczmarski, Wojciech, Barua, Madhabi, Kuchna, Izabela, Nowicki, Krzysztof, Wang, Kuo-Chiang, Wegiel, Jarek, Ma, Shuang Yang, Frackowiak, Janusz, Mazur-Kolecka, Bozena, Silverman, Wayne P., Reisberg, Barry, Monteiro, Isabel, Leon, Mony de, Wisniewski, Thomas, Dalton, Arthur, Lai, Florence, Hwang, Yu-Wen, Adayev, Tatyana, Liu, Fei, Iqbal, Khalid, Iqbal, Inge-Grundke, Gong, Cheng-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083064/
https://ncbi.nlm.nih.gov/pubmed/21157379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e318202bfa1
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