The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

The gene encoding the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A (DYRK1A) is located in the Down syndrome (DS) critical region of chromosome 21. The third copy of DYRK1A is believed to contribute to abnormal brain development in patients with DS. In vitro studi...

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Detalhes bibliográficos
Main Authors: Wegiel, Jerzy, Dowjat, Karol, Kaczmarski, Wojciech, Kuchna, Izabela, Nowicki, Krzysztof, Frackowiak, Janusz, Kolecka, Bozena Mazur, Wegiel, Jarek, Silverman, Wayne P., Reisberg, Barry, deLeon, Mony, Wisniewski, Thomas, Gong, Cheng-Xin, Liu, Fei, Adayev, Tatyana, Chen-Hwang, Mo-Chou, Hwang, Yu-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656568/
https://ncbi.nlm.nih.gov/pubmed/18696092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-008-0419-6
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