The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

The gene encoding the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A (DYRK1A) is located in the Down syndrome (DS) critical region of chromosome 21. The third copy of DYRK1A is believed to contribute to abnormal brain development in patients with DS. In vitro studi...

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Bibliografiske detaljer
Main Authors: Wegiel, Jerzy, Dowjat, Karol, Kaczmarski, Wojciech, Kuchna, Izabela, Nowicki, Krzysztof, Frackowiak, Janusz, Kolecka, Bozena Mazur, Wegiel, Jarek, Silverman, Wayne P., Reisberg, Barry, deLeon, Mony, Wisniewski, Thomas, Gong, Cheng-Xin, Liu, Fei, Adayev, Tatyana, Chen-Hwang, Mo-Chou, Hwang, Yu-Wen
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656568/
https://ncbi.nlm.nih.gov/pubmed/18696092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-008-0419-6
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