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Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
Adults with Down syndrome (DS) develop Alzheimer neurofibrillary degeneration in the brain, but the underlying molecular mechanism is unknown. Here, we report that the presence of an extra copy of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A (Dyrk1A) gene due to trisomy 21 re...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Federation of American Societies for Experimental Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518253/ https://ncbi.nlm.nih.gov/pubmed/18509201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-104539 |
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