Endothelin-1 Mediates Hypoxia-Induced Increases in Vascular Collagen in the Newborn Mouse Lung

Endothelin-1 (ET-1) mediates hypoxia-mediated pulmonary vascular remodeling (HPVR), and endothelin-A receptor (ET-AR) blockade prevents HPVR in newborn mice. Our objective was to determine postnatal effects of chronic hypoxia and/or ET-AR blockade on lung ET-1, ET-AR, ET-BR, and vascular collagen an...

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Bibliographic Details
Main Authors: AMBALAVANAN, NAMASIVAYAM, LI, PENG, BULGER, ARLENE, MURPHY-ULLRICH, JOANNE, OPARIL, SUZANNE, CHEN, YIU-FAI
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517238/
https://ncbi.nlm.nih.gov/pubmed/17413856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1203/pdr.0b013e318045beae
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