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A Single Amino Acid Difference between Ether-a-go-go-Related Gene Channel Subtypes Determines Differential Sensitivity to a Small Molecule Activator
Activators of human ether-a-go-go-related gene 1 (hERG1) channels, such as (3R,4R)-4-[3-(6-methoxy-quinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid (RPR260243), reverse the effect of hERG1 blockers and shorten the duration of cardiac action potenti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2517227/ https://ncbi.nlm.nih.gov/pubmed/18162604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.043018 |
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