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Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator
Activation of human ether-a-go-go-related gene 1 (hERG1) K(+) channels mediates cardiac action potential repolarization. Drugs that activate hERG1 channels represent a mechanism-based approach for the treatment of long QT syndrome, a disorder of cardiac repolarization associated with ventricular arr...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1959467/ https://ncbi.nlm.nih.gov/pubmed/17693551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703934104 |
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