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Molecular Determinants of Human ether-à-go-go-Related Gene 1 (hERG1) K(+) Channel Activation by NS1643
Human ether-à-go-go-related gene 1 (hERG1) channels conduct the rapid delayed rectifier K(+) current, I(Kr), an important determinant of action potential repolarization in mammals, including humans. Reduced I(Kr) function caused by mutations in KCNH2 or drug block of hERG1 channels prolongs the QT i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014275/ https://ncbi.nlm.nih.gov/pubmed/20876384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.067728 |
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