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Topoisomerase I Requirement for Death Receptor-induced Apoptotic Nuclear Fission
Topoisomerase I (Top1) is known to relax DNA supercoiling generated by transcription, replication, and chromatin remodeling. However, it can be trapped on DNA as cleavage complexes (Top1cc) by oxidative and carcinogenic DNA lesions, base damage, and camptothecin treatment. We show here that Top1 is...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516995/ https://ncbi.nlm.nih.gov/pubmed/18556653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801146200 |
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