Phosphorylation of BLM, Dissociation from Topoisomerase IIIα, and Colocalization with γ-H2AX after Topoisomerase I-Induced Replication Damage

Topoisomerase I-associated DNA single-strand breaks selectively trapped by camptothecins are lethal after being converted to double-strand breaks by replication fork collisions. BLM (Bloom's syndrome protein), a RecQ DNA helicase, and topoisomerase IIIα (Top3α) appear essential for the resoluti...

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Bibliographic Details
Main Authors: Rao, V. Ashutosh, Fan, Angela M., Meng, LingHua, Doe, Christopher F., North, Phillip S., Hickson, Ian D., Pommier, Yves
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Chromosome Structure and Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265790/
https://ncbi.nlm.nih.gov/pubmed/16199871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.20.8925-8937.2005
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