Human Topoisomerase IIIα Is a Single-stranded DNA Decatenase That Is Stimulated by BLM and RMI1

Human topoisomerase IIIα is a type IA DNA topoisomerase that functions with BLM and RMI1 to resolve DNA replication and recombination intermediates. BLM, human topoisomerase IIIα, and RMI1 catalyze the dissolution of double Holliday junctions into noncrossover products via a strand-passage mechanism...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Jay, Bachrati, Csanad Z., Ou, Jiongwen, Hickson, Ian D., Brown, Grant W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898442/
https://ncbi.nlm.nih.gov/pubmed/20445207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123216
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