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Topoisomerase I Requirement for Death Receptor-induced Apoptotic Nuclear Fission

Topoisomerase I (Top1) is known to relax DNA supercoiling generated by transcription, replication, and chromatin remodeling. However, it can be trapped on DNA as cleavage complexes (Top1cc) by oxidative and carcinogenic DNA lesions, base damage, and camptothecin treatment. We show here that Top1 is...

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Detalhes bibliográficos
Main Authors: Sordet, Olivier, Goldman, Abby, Redon, Christophe, Solier, Stéphanie, Rao, V. Ashutosh, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516995/
https://ncbi.nlm.nih.gov/pubmed/18556653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801146200
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