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Kinetics and Mechanisms of Activation of α-Amino Acid Ester Prodrugs of Camptothecins
The α-amino acid ester prodrugs of the antitumor agent camptothecin and a more potent, lipophilic silatecan analog, DB-67, have been shown by NMR spectroscopy and quantitative kinetic analyses to undergo quantitative conversion to their pharmacologically active lactones via a non-enzymatic mechanism...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516925/ https://ncbi.nlm.nih.gov/pubmed/16821794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060016l |
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