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A Series of α-Amino Acid Ester Prodrugs of Camptothecin: In vitro Hydrolysis and A549 Human Lung Carcinoma Cell Cytotoxicity

The objective of the present study was to identify a camptothecin (CPT) prodrug with optimal release and cytotoxicity properties for immobilization on a passively targeted microparticle delivery system. A series of α-amino acid ester prodrugs of CPT were synthesized, characterized and evaluated. Fou...

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Detalhes bibliográficos
Main Authors: Deshmukh, Manjeet, Chao, Piyun, Kutscher, Hilliard L., Gao, Dayuan, Sinko, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901077/
https://ncbi.nlm.nih.gov/pubmed/20063889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901029n
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