GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein

Increased α-synuclein gene (SNCA) dosage due to locus multiplication causes autosomal dominant Parkinson's disease (PD). Variation in SNCA expression may be critical in common, genetically complex PD but the underlying regulatory mechanism is unknown. We show that SNCA and the heme metabolism g...

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Detalles Bibliográficos
Autores principales: Scherzer, Clemens R., Grass, Jeffrey A., Liao, Zhixiang, Pepivani, Imelda, Zheng, Bin, Eklund, Aron C., Ney, Paul A., Ng, Juliana, McGoldrick, Meghan, Mollenhauer, Brit, Bresnick, Emery H., Schlossmacher, Michael G.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504800/
https://ncbi.nlm.nih.gov/pubmed/18669654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802437105
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