GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein

Increased α-synuclein gene (SNCA) dosage due to locus multiplication causes autosomal dominant Parkinson's disease (PD). Variation in SNCA expression may be critical in common, genetically complex PD but the underlying regulatory mechanism is unknown. We show that SNCA and the heme metabolism g...

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Detalhes bibliográficos
Main Authors: Scherzer, Clemens R., Grass, Jeffrey A., Liao, Zhixiang, Pepivani, Imelda, Zheng, Bin, Eklund, Aron C., Ney, Paul A., Ng, Juliana, McGoldrick, Meghan, Mollenhauer, Brit, Bresnick, Emery H., Schlossmacher, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504800/
https://ncbi.nlm.nih.gov/pubmed/18669654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802437105
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