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Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K(+) channels

Inward-rectifier K(+) (Kir) channels play many important biological roles and are emerging as important therapeutic targets. Subtype-specific inhibitors would be useful tools for studying the channels' physiological functions. Unfortunately, available K(+) channel inhibitors generally lack the...

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Autori principali: Ramu, Yajamana, Xu, Yanping, Lu, Zhe
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504780/
https://ncbi.nlm.nih.gov/pubmed/18669667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802850105
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