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Evidence for Sequential Ion-binding Loci along the Inner Pore of the IRK1 Inward-rectifier K(+) Channel

Steep rectification in IRK1 (Kir2.1) inward-rectifier K(+) channels reflects strong voltage dependence (valence of ∼5) of channel block by intracellular cationic blockers such as the polyamine spermine. The observed voltage dependence primarily results from displacement, by spermine, of up to five K...

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Detalhes bibliográficos
Main Authors: Shin, Hyeon-Gyu, Xu, Yanping, Lu, Zhe
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266567/
https://ncbi.nlm.nih.gov/pubmed/16043774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509296
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