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Evidence for Sequential Ion-binding Loci along the Inner Pore of the IRK1 Inward-rectifier K(+) Channel
Steep rectification in IRK1 (Kir2.1) inward-rectifier K(+) channels reflects strong voltage dependence (valence of ∼5) of channel block by intracellular cationic blockers such as the polyamine spermine. The observed voltage dependence primarily results from displacement, by spermine, of up to five K...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2266567/ https://ncbi.nlm.nih.gov/pubmed/16043774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509296 |
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