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Nonmuscle myosin II-B is required for normal development of the mouse heart

We used targeted gene disruption in mice to ablate nonmuscle myosin heavy chain B (NMHC-B), one of the two isoforms of nonmuscle myosin II present in all vertebrate cells. Approximately 65% of the NMHC-B(−/−) embryos died prior to birth, and those that were born suffered from congestive heart failur...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tullio, Antonella N., Accili, Domenico, Ferrans, Victor J., Yu, Zu-Xi, Takeda, Kazuyo, Grinberg, Alexander, Westphal, Heiner, Preston, Yvette A., Adelstein, Robert S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1997
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC24969/
https://ncbi.nlm.nih.gov/pubmed/9356462
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