Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B–depleted mice

Complete ablation of nonmuscle myosin heavy chain II-B (NMHC-B) in mice resulted in cardiac and brain defects that were lethal during embryonic development or on the day of birth. In this paper, we report on the generation of mice with decreased amounts of NMHC-B. First, we generated B(ΔI)/B(ΔI) mic...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Üren, Deniz, Hwang, Hweung-Kon, Hara, Yoshinobu, Takeda, Kazuyo, Kawamoto, Sachiyo, Tullio, Antonella N., Yu, Zu-Xi, Ferrans, Victor J., Tresser, Nancy, Grinberg, Alexander, Preston, Yvette A., Adelstein, Robert S.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2000
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC289177/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10712438/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8199
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