Hybrid Ty1/HIV-1 elements used to detect inhibitors and monitor the activity of HIV-1 reverse transcriptase

We previously demonstrated that hybrid retrotransposons composed of the yeast Ty1 element and the reverse transcriptase (RT) of HIV-1 are active in the yeast Saccharomyces cerevisiae. The RT activity of these hybrid Ty1/HIV-1 (his3AI/AIDS RT; HART) elements can be monitored by using a simple genetic...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Nissley, Dwight V., Boyer, Paul L., Garfinkel, David J., Hughes, Stephen H., Strathern, Jeffrey N.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1998
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24958/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13905
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