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Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp
DNA polymerases attach to the DNA sliding clamp through a common overlapping binding site. We identify a small-molecule compound that binds the protein-binding site in the Escherichia coli β-clamp and differentially affects the activity of DNA polymerases II, III, and IV. To understand the molecular...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2495014/ https://ncbi.nlm.nih.gov/pubmed/18678908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804754105 |
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