Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp

DNA polymerases attach to the DNA sliding clamp through a common overlapping binding site. We identify a small-molecule compound that binds the protein-binding site in the Escherichia coli β-clamp and differentially affects the activity of DNA polymerases II, III, and IV. To understand the molecular...

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Detaylı Bibliyografya
Asıl Yazarlar: Georgescu, Roxana E., Yurieva, Olga, Kim, Seung-Sup, Kuriyan, John, Kong, Xiang-Peng, O'Donnell, Mike
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2495014/
https://ncbi.nlm.nih.gov/pubmed/18678908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804754105
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