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How a DNA polymerase clamp loader opens a sliding clamp

Processive chromosomal replication relies on sliding DNA clamps, which are loaded onto DNA by pentameric clamp loader complexes belonging to the AAA+ family of ATPases. We present structures for the ATP-bound state of the clamp loader complex from bacteriophage T4, bound to an open clamp and primer-...

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Autors principals: Kelch, Brian A., Makino, Debora L., O’Donnell, Mike, Kuriyan, John
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281585/
https://ncbi.nlm.nih.gov/pubmed/22194570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1211884
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