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Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp
DNA polymerases attach to the DNA sliding clamp through a common overlapping binding site. We identify a small-molecule compound that binds the protein-binding site in the Escherichia coli β-clamp and differentially affects the activity of DNA polymerases II, III, and IV. To understand the molecular...
Tallennettuna:
| Päätekijät: | , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2495014/ https://ncbi.nlm.nih.gov/pubmed/18678908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804754105 |
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