EGF antagonizes TGF-β-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF

We previously reported that neutrophil elastase (NE) downregulates transforming growth factor-β (TGF-β)-maintained tropoelastin mRNA levels in lung fibroblasts through transactivation of the epidermal growth factor (EGF) receptor (EGFR)/Mek/Erk pathway, which is dependent on the NE-initiated release...

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Detaylı Bibliyografya
Asıl Yazarlar: Yang, Shenghong, Nugent, Matthew A., Panchenko, Mikhail P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2008
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494790/
https://ncbi.nlm.nih.gov/pubmed/18441095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00289.2007
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