Jab1 antagonizes TGF-β signaling by inducing Smad4 degradation

Tumor suppressor Smad4 is the common signaling effector in the transforming growth factor β (TGF-β) superfamily. Phosphorylated regulatory Smads (R-Smads) interact with Smad4, and the complex translocates into the nucleus to regulate gene transcription. Proper TGF-β signaling requires precise contro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wan, Mei, Cao, Xuesong, Wu, Yalei, Bai, Shuting, Wu, Liyu, Shi, Xingming, Wang, Ning, Cao, Xu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2002
Pynciau:
Scientific Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083965/
https://ncbi.nlm.nih.gov/pubmed/11818334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf024
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