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STAT3 selectively interacts with Smad3 to antagonize TGF-β signaling
Smad and STAT proteins are critical signal transducers and transcription factors in controlling cell growth and tumorigenesis. Here we report that the STAT3 signaling pathway attenuates TGF-β-induced responses through a direct Smad3-STAT3 interplay. Activated STAT3 blunts TGF-β-mediated signaling. D...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4885808/ https://ncbi.nlm.nih.gov/pubmed/26616859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.446 |
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