Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling

Smad7 is a negative feedback product of TGF-β superfamily signaling and fine tunes a plethora of pleiotropic responses induced by TGF-β ligands. However, its noncanonical functions independent of TGF-β signaling remain to be elucidated. Here, we show that Smad7 activates signal transducers and activ...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yu, Yi, Gu, Shuchen, Li, Wenjian, Sun, Chuang, Chen, Fenfang, Xiao, Mu, Wang, Lei, Xu, Dewei, Li, Ye, Ding, Chen, Xia, Zongping, Li, Yi, Ye, Sheng, Xu, Pinglong, Zhao, Bin, Qin, Jun, Chen, Ye-Guang, Lin, Xia, Feng, Xin-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617276/
https://ncbi.nlm.nih.gov/pubmed/28874583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705755114
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