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Jab1 antagonizes TGF-β signaling by inducing Smad4 degradation
Tumor suppressor Smad4 is the common signaling effector in the transforming growth factor β (TGF-β) superfamily. Phosphorylated regulatory Smads (R-Smads) interact with Smad4, and the complex translocates into the nucleus to regulate gene transcription. Proper TGF-β signaling requires precise contro...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083965/ https://ncbi.nlm.nih.gov/pubmed/11818334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf024 |
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